Fujian, China
Business Type:
Trading Company
Year of Establishment:
2017-12-11
Plant Area:
171 square meters
Management System Certification:
ISO 9001, ISO 9000
Average Lead Time:
Peak season lead time: 6-12 months
Off season lead time: within 15 workdays
OEM/ODM Service
Sample Available

Nsi-189, CAS: 1270138-40-3, Pharmaceutical Material manufacturer / supplier in China, offering Pharmaceutical Raw Material Nsi-189 CAS: 1270138-40-3 for Anti-Depression, Tesrone Unoate Pharmaceutical Raw Materials, Factory Direct Pharmaceutical Raw Materials Methyone and so on.

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Pharmaceutical Raw Material Nsi-189 CAS: 1270138-40-3 for Anti-Depression

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Min. Order / Reference FOB Price
10 g US $0.5-1/ g
Port: Shenzhen, China
Production Capacity: 5000kg/Month
Payment Terms: T/T, Western Union, Money Gram, Bitcion
Powder: Yes
Customized: Non-Customized
Certification: GMP, ISO 9001, USP
Suitable for: Elderly, Adult
State: Solid
Purity: >99%

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Basic Info

Model NO.
1270138-40-3
Appearence
White Powder
Grade
Pharmaceutical Grade
Mf
C22h30n4o
MW
366.4998
CAS
1270138-41-4
Trademark
SL
Transport Package
Discreet Package
Specification
25kg/drum
Origin
China

Product Description:


Nsi -189 Powder Pharmaceutical Intermediates Nootropics Depressive Disorder CAS 1270138-40-3
NSI-189
Other Names:NSI-189 Phosphate, (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone
Molecular Formula:C22H30N4O
Formula Weight:366.4998
CAS No.:1270138-40-3
Appearance:off-white powder
Purity:99%



NSI-189 Description

NSI-189 is a benzylphiperizine-aminiopyridine, nootropic and neurogenic research chemical created by Neuralstem, Inc. that was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro. In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression . The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.

The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer's disease, and major depressive disorder (MDD).


 
NSI-189 Benefits

Tests have shown that NSI-189 significantly improved behavioral responses that are associated with depression . In humans it may counter hippocampal atrophy which is seen in disorders such as MDD, reversing their symptoms. A phase 1B randomized, double-blind, placebo-controlled, multiple-dose escalation study conducted over a 28 day period showed behavioral efficacy in 24 patients who were orally administered NSI-189. The efficacy measurements showed a clinically meaningful reduction in cognitive and depressive symptoms across all measures, and appeared to persist over time during follow up for the efficacy assessments which included the Clinical Global Impression - Improvement (CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical Functioning Questionnaire (CPFQ, and the Symptoms of Depression Questionnaire (SDQ)

NSI-189 Dosage and Suggestion:

Studies conducted to evaluate effects of NSI-189 revealed that 40 to 80 mg daily is effective in treating depression and cognitive symptoms amongst healthy patients. In these trials, there are no serious adverse events recorded. Generally, NSI-189 is well tolerated and safe for human use.

 
COA 
 
Product name
 
 
NSI-189
CAS No. 
1270138-40-3
Outer Packing 
 
Production date 
Dec. 15. 2016.
Shelf life 
Dec. 14th. 2019
Standard adopted 
 
in-house standard
Items of analysisSpecificationResults
 
 
Appearance
 
 
Off-white powder
 
 
Confrom
 
 
Identification
 
 
IR and HPLC spectrum shall conform to the standard sample
 
 
conform
 
 
Melting Point
 
 
83ºC~86ºC
 
 
84.3ºC~85.6ºC
 
 
Loss on Drying
 
 
Less than 0.5%
 
 
0.29%
 
 
Purity(On Dried Base,HPLC)
 
 
NLT 99.5 %
 
 
99.62%
 
 
Total Impurity
 
 
Less than 0.5%
 
 
0.33%
 
 
Residue On Ignition
 
 
≤0.2%
 
 
0.16%
 
 
Heavy metal
 
 
≤20ppm
 
 
conform
ConclusionQualified
 
 

Payment and shipment:
Pharmaceutical Raw Material Nsi-189 CAS: 1270138-40-3 for Anti-Depression


If you want to know more about our products,please search
http://www.slsteroid.com/.
 

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